Scientific Data | Linnea: Quality Botanical Ingredients

2025

Cannabizetol, a Novel Cannabinoid: Chemical Synthesis, Anti-inflammatory Activity and Extraction from Cannabis sativa L

L. Pozzi et al.

2025

Revisiting the Reduction of Vinpocetine

S. Borsoi et al.

2025

Efficacy of non-psychotropic Cannabis sativa L. standardized extracts in a model of intestinal inflammation

N. Maranta et al.

2025

Beyond Cannabidiol: The Contribution of Cannabis sativa Phytocomplex to Skin Anti-Inflammatory Activity in Human Skin Keratinocytes

M. Fumagalli et al.

2024

Minor Cannabinoids as Inhibitors of Skin Inflammation: Chemical Synthesis and Biological Evaluation

A. Maiocchi et al.

2022

Cannabidiol has a central role in the NF-kB inhibition of a Cannabis sativa L. extract in human keratinocytes

ZURICH, SWITZERLAND
36th Swiss annual conference for phytotherapy (36. Schweizerische Jahrestagung für Phytotherapie)

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2022

Cannabis sativa L. can reduce inflammation in human keratinocytes thanks to the inhibitory effect of cannabidiol on the NF-кB pathway

BASEL, SWITZERLAND
12th IACM conference on Cannabinoids in medicine, 1st SSCM conference on Cannabis in medicine

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2022

Total Synthesis of (-)-Cannabidiol-C4

P. Marzullo et al.

2021

Convenient Preparation and Spectroscopic Characterization of 7R-Hydroxymatairesinol

E. Colombo et al.

2021

Neuroprotective and Symptomatic Effects of Cannabidiol in an Animal Model of Parkinson’s Disease

C. Giuliano et al.

2020

A PHASE 1 TRIAL OF THE SAFETY, TOLERABILITY AND PHARMACOKINETICS OF CANNABIDIOL ADMINISTERED AS SINGLE-DOSE OIL SOLUTION AND SINGLE AND MULTIPLE DOSES OF A SUBLINGUAL WAFER IN HEALTHY VOLUNTEERS

Hosseini A, McLachlan AJ, Lickliter JD.

2020

Cannabidiol as the substrate in acid-catalyzed intramolecular cyclization

P. Marzullo et al.

2020

Neuroprotective effects of cannabidiol in an animal model of Parkinson’s disease

VIRTUAL EVENT
FENS 2020 Virtual Forum of Neuroscience

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2020

RED CLOVER AND LIFESTYLE CHANGES TO CONTRAST MENOPAUSAL SYMPTOMS IN PREMENOPAUSAL PATIENTS WITH HORMONE‑SENSITIVE BREAST CANCER RECEIVING TAMOXIFEN

C. Ferraris et al.

2020

A phase I trial of the safety, tolerability and pharmacokinetics of cannabidiol administered as single-dose oil solution and single and multiple doses of a sublingual wafer in healthy volunteers

A. Hosseini et al.

2019

Cannabis sativa L. extract and cannabidiol inhibit in vitro mediators of skin inflammation and wound injury

E. Sangiovanni et al.

2019

NEUROPROTECTIVE EFFECTS OF LIGNAN 7-HYDROXYMATAIRESINOL (HMR/LIGNAN®) IN A RODENT MODEL OF PARKINSON’S DISEASE

C. Giuliano et al.

2019

Cannabis sativa L. extract reduces inflammatory markers in human fibroblasts and keratinocytes

INNSBRUCK, AUSTRIA
GA Congress Innsbruck

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2019

Safety, tolerability and pharmacokinetics of ‘pharmaceutical-grade full spectrum Cannabidiol’ administered as single sublingual wafer and oil solution in healthy volunteers

LONDON, UK
CT-Cann

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2019

Comparison of Two Ginkgo biloba L. Extracts on Oxidative Stress and Inflammation Markers in Human Endothelial Cells

S. Piazza et al.

2019

A Novel Standardized Cannabis sativa L. Extract and Its Constituent Cannabidiol Inhibit Human Polymorphonuclear Leukocyte Functions

A. Mabou Tagne et al.

2018

Untargeted rat brain metabolomics after oral administration of a single high dose of cannabidiol

C. Citti et al.

2018

Comparison of a Cannabis sativa L. extract and its derivative Cannabidiol on human polymorphonuclear leukocyte function

VIENNA, AUSTRIA
Cannabis

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2018

Cannabidiol modulates migration and oxidative metabolism in human polymorphonuclear leukocytes

LEIDEN, NETHERLANDS
The 28th annual ICRS Symposium on the Cannabinoids

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2018

The phytocannabinoid Cannabidiol inhibits migration and reactive oxygen species generation in human polymorphonuclear leukocytes

VIENNA, AUSTRIA
The international annual congress on controversies on Cannabis-based medicines

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2018

Anti-inflammatory effects of Cannabis sativa L. in human keratinocytes

SHANGHAI, CHINA
The 66th annual meeting of the society for medicinal plant and natural product research, the 11th Shanghai international conference on traditional Chinese medicine and natural medicine

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2018

Pharmaceutical and biomedical analysis of cannabinoids: A criticalreview

C. Citti et al.

2018

Untargeted rat brain metabolomics after oral administration of asingle high dose of cannabidiol

C. Citti et. Al

2017

Pharmaceutical and biomedical analysis of cannabinoids: a critical review

C. Citti et al.

2017

Anti-inflammatory activity of Cannabis sativa L. extracts in an in vitro model of skin inflammation

BASEL, SWITZERLAND
65th annual meeting of the society for medicinal plant and natural products research

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2017

Molecular fingerprinting of a Cannabis sativa L. extract in medium-chain triglyceride (MCT) oil

RIMINI, ITALY
Recent developments in pharmaceutical analysis

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2017

Analysis of cannabinoids in commercial hemp seed oil and decarboxylation kinetics studies of cannabidiolic acid (CBDA)

C. Citti et. Al

2016

EFFECTS OF A STANDARDISED EXTRACT OF TRIFOLIUM PRATENSE (PROMENSIL) AT A DOSAGE OF 80 MG IN THE TREATMENT OF MENOPAUSAL HOT FLUSHES: A SYSTEMATIC REVIEW AND META-ANALYSIS

SP. Myers, V. Vigar

2014

Isoflavone content and estrogenic activity of different batches of red clover (Trifolium pratense L.) extracts: An in vitro study in MCF-7 cells

P. Spagnuolo et al.

2013

PHARMACOKINETICS AND BIOAVAILABILITY OF PLANT LIGNAN 7-HYDROXYMATAIRESINOL AND EFFECTS ON SERUM ENTEROLACTONE AND CLINICAL SYMPTOMS IN POSTMENOPAUSAL WOMEN: A SINGLE- BLINDED, PARALLEL, DOSE-COMPARISON STUDY

J. K. Udani MD et al.

2011

THE EFFECT OF RED CLOVER ISOFLAVONE SUPPLEMENTATION OVER VASOMOTOR AND MENOPAUSAL SYMPTOMS IN POSTMENOPAUSAL WOMEN

M. Lipovac et al.

2009

IMMUNOMODULATORY ACTIVITY OF THE LIGNAN 7-HYDROXYMATAIRESINOL POTASSIUM ACETATE (HMR/LIGNAN®) EXTRACTED FROM THE HEARTWOOD OF NORWAY SPRUCE (PICEA ABIES)

M. Cosentino et al.

2008

RED CLOVER ISOFLAVONES ARE SAFE AND WELL TOLERATED IN WOMEN WITH A FAMILY HISTORY OF BREAST CANCER

T. J. Powles et al.

2007

ESTROGENIC ACTIVITY OF 7-HYDROXYMATAIRESINOL POTASSIUM ACETATE (HMR/LIGNAN®) FROM NORWAY SPRUCE (PICEA ABIES) KNOTS AND OF ITS ACTIVE METABOLITE ENTEROLACTONE IN MCF-7 CELLS

M. Cosentino et al.

2005

THE EFFECT OF RED CLOVER ISOFLAVONES ON MENOPAUSAL SYMPTOMS, LIPIDS AND VAGINAL CYTOLOGY IN MENOPAUSAL WOMEN: A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY

L. A. Hidalgo et al.

2005

A THIRTEEN WEEK DIETARY TOXICITY STUDY WITH 7-HYDROXYMATAIRESINOL POTASSIUM ACETATE (HMRLIGNAN) IN RATS

B. Lina et al.

2004

PRENATAL DEVELOPMENTAL TOXICITY STUDY WITH 7-HYDROXYMATAIRESINOL POTASSIUM ACETATE (HMRLIGNAN) IN RATS

A. Wolterbeek et al.

2004

CHEMOPREVENTIVE EFFECTS OF HYDROXYMATAIRESINOL ON UTERINE CARCINOGENESIS IN DONRYU RATS

S. Katsuda et al.

2004

RED CLOVER-DERIVED ISOFLAVONES AND MAMMOGRAPHIC BREAST DENSITY: A DOUBLE-BLIND, RANDOMIZED, PLACEBO-CONTROLLED TRIAL

C. Atkinson et al.

2003

THE EFFECTS OF PHYTOESTROGEN ISOFLAVONES ON BONE DENSITY IN WOMEN: A DOUBLE-BLIND, RANDOMIZED, PLACEBO-CONTROLLED TRIAL

C. Atkinson et al.

2003

ISOFLAVONES REDUCE ARTERIAL STIFFNESS: A PLACEBO-CONTROLLED STUDY IN MEN AND POSTMENOPAUSAL WOMEN

H. J. Teede et al.

2002

ANTIOXIDANT AND ANTITUMOR EFFECTS OF HYDROXYMATAIRESINOL (HM-3000, HMR), A LIGNAN ISOLATED FROM THE KNOTS OF SPRUCE

L. Kangas et al.

2002

ISOFLAVONES FROM RED CLOVER (PROMENSIL®) SIGNIFICANTLY REDUCE MENOPAUSAL HOT FLUSH SYMPTOMS COMPARED WITH PLACEBO

Peter H.M. van de Weijer, Ronald Barentsen

2001

A DOUBLE-BLIND RANDOMIZED CONTROLLED TRIAL OF ISOFLAVONES IN THE TREATMENT OF CYCLICAL MASTALGIA

D. M. Ingram et al.

2001

THE EFFECT OF ISOFLAVONES EXTRACTED FROM RED CLOVER (RIMOSTIL) ON LIPID AND BONE METABOLISM

P. B. Clifton-Bligh et al.

1999

The effects of isoflavones derived from red clover on vasomotor symptoms and endometrial thickness

L. B. Nachtigall et al.

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1998

Isoflavones from red clover improve systemicarterial compliance but not plasma lipids in menopausal women

P. J. Nestel et al.

Linnea’s Botanical Ingredients Info & Inquiry

LINNEA®SCIENTIFIC DATA

Cannabizetol, a Novel Cannabinoid: Chemical Synthesis, Anti-inflammatory Activity and Extraction from Cannabis sativa L

Revisiting the Reduction of Vinpocetine

Efficacy of non-psychotropic Cannabis sativa L. standardized extracts in a model of intestinal inflammation

Beyond Cannabidiol: The Contribution of Cannabis sativa Phytocomplex to Skin Anti-Inflammatory Activity in Human Skin Keratinocytes

Minor Cannabinoids as Inhibitors of Skin Inflammation: Chemical Synthesis and Biological Evaluation

Cannabidiol has a central role in the NF-kB inhibition of a Cannabis sativa L. extract in human keratinocytes

Cannabis sativa L. can reduce inflammation in human keratinocytes thanks to the inhibitory effect of cannabidiol on the NF-кB pathway

Total Synthesis of (-)-Cannabidiol-C4

Convenient Preparation and Spectroscopic Characterization of 7R-Hydroxymatairesinol

Neuroprotective and Symptomatic Effects of Cannabidiol in an Animal Model of Parkinson’s Disease

A PHASE 1 TRIAL OF THE SAFETY, TOLERABILITY AND PHARMACOKINETICS OF CANNABIDIOL ADMINISTERED AS SINGLE-DOSE OIL SOLUTION AND SINGLE AND MULTIPLE DOSES OF A SUBLINGUAL WAFER IN HEALTHY VOLUNTEERS

Cannabidiol as the substrate in acid-catalyzed intramolecular cyclization

Neuroprotective effects of cannabidiol in an animal model of Parkinson’s disease

RED CLOVER AND LIFESTYLE CHANGES TO CONTRAST MENOPAUSAL SYMPTOMS IN PREMENOPAUSAL PATIENTS WITH HORMONE‑SENSITIVE BREAST CANCER RECEIVING TAMOXIFEN

A phase I trial of the safety, tolerability and pharmacokinetics of cannabidiol administered as single-dose oil solution and single and multiple doses of a sublingual wafer in healthy volunteers

Cannabis sativa L. extract and cannabidiol inhibit in vitro mediators of skin inflammation and wound injury

NEUROPROTECTIVE EFFECTS OF LIGNAN 7-HYDROXYMATAIRESINOL (HMR/LIGNAN®) IN A RODENT MODEL OF PARKINSON’S DISEASE

Cannabis sativa L. extract reduces inflammatory markers in human fibroblasts and keratinocytes

Safety, tolerability and pharmacokinetics of ‘pharmaceutical-grade full spectrum Cannabidiol’ administered as single sublingual wafer and oil solution in healthy volunteers

Comparison of Two Ginkgo biloba L. Extracts on Oxidative Stress and Inflammation Markers in Human Endothelial Cells

A Novel Standardized Cannabis sativa L. Extract and Its Constituent Cannabidiol Inhibit Human Polymorphonuclear Leukocyte Functions

Untargeted rat brain metabolomics after oral administration of a single high dose of cannabidiol

Comparison of a Cannabis sativa L. extract and its derivative Cannabidiol on human polymorphonuclear leukocyte function

Cannabidiol modulates migration and oxidative metabolism in human polymorphonuclear leukocytes

The phytocannabinoid Cannabidiol inhibits migration and reactive oxygen species generation in human polymorphonuclear leukocytes

Anti-inflammatory effects of Cannabis sativa L. in human keratinocytes

Pharmaceutical and biomedical analysis of cannabinoids: A criticalreview

Untargeted rat brain metabolomics after oral administration of asingle high dose of cannabidiol

Pharmaceutical and biomedical analysis of cannabinoids: a critical review

Anti-inflammatory activity of Cannabis sativa L. extracts in an in vitro model of skin inflammation

Molecular fingerprinting of a Cannabis sativa L. extract in medium-chain triglyceride (MCT) oil

Analysis of cannabinoids in commercial hemp seed oil and decarboxylation kinetics studies of cannabidiolic acid (CBDA)

EFFECTS OF A STANDARDISED EXTRACT OF TRIFOLIUM PRATENSE (PROMENSIL) AT A DOSAGE OF 80 MG IN THE TREATMENT OF MENOPAUSAL HOT FLUSHES: A SYSTEMATIC REVIEW AND META-ANALYSIS

Isoflavone content and estrogenic activity of different batches of red clover (Trifolium pratense L.) extracts: An in vitro study in MCF-7 cells

PHARMACOKINETICS AND BIOAVAILABILITY OF PLANT LIGNAN 7-HYDROXYMATAIRESINOL AND EFFECTS ON SERUM ENTEROLACTONE AND CLINICAL SYMPTOMS IN POSTMENOPAUSAL WOMEN: A SINGLE- BLINDED, PARALLEL, DOSE-COMPARISON STUDY

THE EFFECT OF RED CLOVER ISOFLAVONE SUPPLEMENTATION OVER VASOMOTOR AND MENOPAUSAL SYMPTOMS IN POSTMENOPAUSAL WOMEN

IMMUNOMODULATORY ACTIVITY OF THE LIGNAN 7-HYDROXYMATAIRESINOL POTASSIUM ACETATE (HMR/LIGNAN®) EXTRACTED FROM THE HEARTWOOD OF NORWAY SPRUCE (PICEA ABIES)

RED CLOVER ISOFLAVONES ARE SAFE AND WELL TOLERATED IN WOMEN WITH A FAMILY HISTORY OF BREAST CANCER

ESTROGENIC ACTIVITY OF 7-HYDROXYMATAIRESINOL POTASSIUM ACETATE (HMR/LIGNAN®) FROM NORWAY SPRUCE (PICEA ABIES) KNOTS AND OF ITS ACTIVE METABOLITE ENTEROLACTONE IN MCF-7 CELLS

THE EFFECT OF RED CLOVER ISOFLAVONES ON MENOPAUSAL SYMPTOMS, LIPIDS AND VAGINAL CYTOLOGY IN MENOPAUSAL WOMEN: A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY

A THIRTEEN WEEK DIETARY TOXICITY STUDY WITH 7-HYDROXYMATAIRESINOL POTASSIUM ACETATE (HMRLIGNAN) IN RATS

PRENATAL DEVELOPMENTAL TOXICITY STUDY WITH 7-HYDROXYMATAIRESINOL POTASSIUM ACETATE (HMRLIGNAN) IN RATS

CHEMOPREVENTIVE EFFECTS OF HYDROXYMATAIRESINOL ON UTERINE CARCINOGENESIS IN DONRYU RATS

RED CLOVER-DERIVED ISOFLAVONES AND MAMMOGRAPHIC BREAST DENSITY: A DOUBLE-BLIND, RANDOMIZED, PLACEBO-CONTROLLED TRIAL

THE EFFECTS OF PHYTOESTROGEN ISOFLAVONES ON BONE DENSITY IN WOMEN: A DOUBLE-BLIND, RANDOMIZED, PLACEBO-CONTROLLED TRIAL

ISOFLAVONES REDUCE ARTERIAL STIFFNESS: A PLACEBO-CONTROLLED STUDY IN MEN AND POSTMENOPAUSAL WOMEN

ANTIOXIDANT AND ANTITUMOR EFFECTS OF HYDROXYMATAIRESINOL (HM-3000, HMR), A LIGNAN ISOLATED FROM THE KNOTS OF SPRUCE

ISOFLAVONES FROM RED CLOVER (PROMENSIL®) SIGNIFICANTLY REDUCE MENOPAUSAL HOT FLUSH SYMPTOMS COMPARED WITH PLACEBO

A DOUBLE-BLIND RANDOMIZED CONTROLLED TRIAL OF ISOFLAVONES IN THE TREATMENT OF CYCLICAL MASTALGIA

THE EFFECT OF ISOFLAVONES EXTRACTED FROM RED CLOVER (RIMOSTIL) ON LIPID AND BONE METABOLISM

The effects of isoflavones derived from red clover on vasomotor symptoms and endometrial thickness

Isoflavones from red clover improve systemicarterial compliance but not plasma lipids in menopausal women

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