Following our previously published findings on the anti-inflammatory potential of CBD-rich extracts in psoriasis models, we’re proud to share a significant update developed in collaboration with the Pharmacognosy team at the University of Milan, led by Prof. Mario Dell’Agli.
This newly published study represents the culmination of an extensive dataset exploring the anti-inflammatory activity of the Cannabis sativa phytocomplex in human skin keratinocytes. Using a bioguided assay, the phytocomplex was fractionated to identify the most active components. Key findings:
- Lipophilic fractions, rich in cannabinoids, terpenes and cannflavins, showed the strongest anti-inflammatory activity.
- Pure CBD, along with CBG and THC, proved to be among the most active constituents—but the full synergistic effect lies in the complexity of the entire phytocomplex.
- The wide variability in response highlights the importance of utilizing standardized extracts to obtain reproducible data
As stated in the paper: “This study highlights CBD’s significant role in reducing inflammation in human keratinocytes and underscores the need to consider the synergistic interactions of several molecules within Cannabis sativa extracts for maximum efficacy.”
While further investigation is needed, this project gives us unparalleled insights into the secondary composition of cannabis. Importantly, these findings support Linnea’s patent on its Cannabis sativa extracts, already granted in Italy and currently expanding globally.